Motif ID: MEF2{A,B,C,D}.p2

Z-value: 4.397


Transcription factors associated with MEF2{A,B,C,D}.p2:

Gene SymbolEntrez IDGene Name
MEF2A 4205 myocyte enhancer factor 2A
MEF2B 100271849 myocyte enhancer factor 2B
MEF2BNB-MEF2B 4207 MEF2BNB-MEF2B readthrough
MEF2C 4208 myocyte enhancer factor 2C
MEF2D 4209 myocyte enhancer factor 2D

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MEF2Cchr5_-_882356240.751.2e-03Click!
MEF2Dchr1_-_154737130-0.515.4e-02Click!
MEF2Achr15_+_979907050.371.8e-01Click!
MEF2Bchr19_-_19142053-0.195.0e-01Click!
LOC729991-MEF2Bchr19_-_19163916-0.107.2e-01Click!


Activity profile for motif MEF2{A,B,C,D}.p2.

activity profile for motif MEF2{A,B,C,D}.p2


Sorted Z-values histogram for motif MEF2{A,B,C,D}.p2

Sorted Z-values for motif MEF2{A,B,C,D}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MEF2{A,B,C,D}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_-_75085754 8.919 NM_001114133
SYNPO2L
synaptopodin 2-like
chr2_-_210876560 8.183 NM_079422
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr10_+_69539255 8.038 NM_032578
MYPN
myopalladin
chr17_-_31548167 7.924 NM_001001437
NM_021006
CCL3L3
CCL3
CCL3L1
chemokine (C-C motif) ligand 3-like 3
chemokine (C-C motif) ligand 3
chemokine (C-C motif) ligand 3-like 1
chr10_-_69095362 7.915 NM_001127384
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr12_+_79625538 7.848 NM_002469
MYF6
myogenic factor 6 (herculin)
chr12_-_55931172 7.409 NM_145064
STAC3
SH3 and cysteine rich domain 3
chr11_-_19180092 7.326 NM_001127656
NM_003476
CSRP3

cysteine and glycine-rich protein 3 (cardiac LIM protein)

chr2_+_88148413 7.134 NM_198274
SMYD1
SET and MYND domain containing 1
chr3_-_39209075 6.754 NM_194293
NM_001198621
XIRP1

xin actin-binding repeat containing 1

chr1_-_199657468 6.469 NM_003281
TNNI1
troponin I type 1 (skeletal, slow)
chr10_+_50177192 6.454 NM_001135196
NM_199459
C10orf71

chromosome 10 open reading frame 71

chr10_-_75080784 5.965 NM_024875
SYNPO2L
synaptopodin 2-like
chr4_+_169654742 5.849 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chr6_-_139654807 5.842 NM_153235
TXLNB
taxilin beta
chr4_-_23500706 5.833 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr1_+_154478574 5.661 NM_199173
BGLAP
bone gamma-carboxyglutamate (gla) protein
chr15_+_76345577 5.509 NM_001130183
DNAJA4
DnaJ (Hsp40) homolog, subfamily A, member 4
chr2_-_105421661 5.495 NM_201557
FHL2
four and a half LIM domains 2
chr2_-_179623030 5.411 NM_173648
CCDC141
coiled-coil domain containing 141
chr5_+_155686333 5.288 NM_000337
NM_001128209
NM_172244
SGCD


sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)


chrX_-_21686079 5.143 NM_014332
SMPX
small muscle protein, X-linked
chr5_-_142057692 5.037 NM_001144934
NM_001144935
FGF1

fibroblast growth factor 1 (acidic)

chr2_+_238712101 4.982 NM_198582
KLHL30
kelch-like 30 (Drosophila)
chr1_+_40508336 4.969 ZMPSTE24
zinc metallopeptidase (STE24 homolog, S. cerevisiae)
chr3_+_137224266 4.967 NM_181897
PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chr10_+_80569464 4.796 ZMIZ1
zinc finger, MIZ-type containing 1
chr8_+_1980564 4.752 NM_003970
MYOM2
myomesin (M-protein) 2, 165kDa
chr5_+_244625 4.646 NM_001080478
LRRC14B
leucine rich repeat containing 14B
chr1_-_16217025 4.499 HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr22_-_49363711 4.440 NM_004377
NM_152246
NM_001145134
NM_001145135
NM_001145136
NM_152245
CPT1B





carnitine palmitoyltransferase 1B (muscle)





chr11_+_1897374 4.348 NM_001042780
NM_001042781
NM_001042782
NM_006757
TNNT3



troponin T type 3 (skeletal, fast)



chr14_+_99309688 4.324 EML1
echinoderm microtubule associated protein like 1
chr2_+_220007943 4.320 NM_005876
SPEG
SPEG complex locus
chr12_+_15590811 4.305 PTPRO
protein tyrosine phosphatase, receptor type, O
chrX_-_77801480 4.248 NM_152694
ZCCHC5
zinc finger, CCHC domain containing 5
chr5_-_150501393 4.213 NM_001193544
ANXA6
annexin A6
chr4_+_114190233 4.212 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr5_+_53787187 4.180 NM_006308
HSPB3
heat shock 27kDa protein 3
chr12_+_15590552 4.116 NM_030668
NM_030669
NM_030670
NM_030671
PTPRO



protein tyrosine phosphatase, receptor type, O



chr10_+_88418243 4.115 NM_001080116
NM_001080114
NM_001080115
NM_001171611
NM_007078
LDB3




LIM domain binding 3




chr2_+_85774924 4.077 NM_006433
NM_012483
GNLY

granulysin

chr17_+_39603599 4.028 NM_080863
ASB16
ankyrin repeat and SOCS box containing 16
chr17_-_10265991 3.831 NM_002472
MYH8
myosin, heavy chain 8, skeletal muscle, perinatal
chr6_+_42896771 3.809 NM_015349
KIAA0240
KIAA0240
chr5_-_140875591 3.756 DIAPH1
diaphanous homolog 1 (Drosophila)
chr2_+_233099113 3.750 NM_000751
CHRND
cholinergic receptor, nicotinic, delta
chr12_-_242255 3.715 NM_001190997
NM_016615
SLC6A13

solute carrier family 6 (neurotransmitter transporter, GABA), member 13

chr17_+_35075124 3.710 NM_003673
TCAP
titin-cap (telethonin)
chr1_-_115039614 3.709 NM_000036
NM_001172626
AMPD1

adenosine monophosphate deaminase 1

chr16_-_49205063 3.659


chr1_-_199613427 3.574 NM_000364
NM_001001430
NM_001001431
NM_001001432
TNNT2



troponin T type 2 (cardiac)



chr11_-_62213946 3.566 NM_203422
LRRN4CL
LRRN4 C-terminal like
chr11_-_62213577 3.563 LRRN4CL
LRRN4 C-terminal like
chr13_-_59223074 3.505


chr4_+_120276386 3.479 NM_016599
MYOZ2
myozenin 2
chr14_+_23670514 3.421 NM_203402
FITM1
fat storage-inducing transmembrane protein 1
chr11_+_1816808 3.409 NM_003282
TNNI2
troponin I type 2 (skeletal, fast)
chr15_+_61676604 3.375 NM_203373
FBXL22
F-box and leucine-rich repeat protein 22
chr3_+_195336631 3.362 HES1
hairy and enhancer of split 1, (Drosophila)
chr5_-_16561936 3.361 NM_019000
FAM134B
family with sequence similarity 134, member B
chr1_-_199613406 3.356 TNNT2
troponin T type 2 (cardiac)
chr3_+_195336625 3.352 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr3_-_57301749 3.343 NM_001142733
ASB14
ankyrin repeat and SOCS box containing 14
chr8_-_72431274 3.307 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr15_+_76171981 3.299 NM_001101404
SH2D7
SH2 domain containing 7
chr13_+_75232797 3.278 NM_015842
LMO7
LIM domain 7
chr15_+_40427592 3.184 NM_212465
CAPN3
calpain 3, (p94)
chr3_+_120982020 3.181 NM_003889
NM_033013
NR1I2

nuclear receptor subfamily 1, group I, member 2

chr17_-_10500189 3.161 NM_002470
MYH3
myosin, heavy chain 3, skeletal muscle, embryonic
chr7_+_18501876 3.159 NM_014707
NM_178423
HDAC9

histone deacetylase 9

chr6_+_53991672 3.153 NM_138569
C6orf142
chromosome 6 open reading frame 142
chr3_+_8750485 3.130 NM_033337
NM_001234
CAV3

caveolin 3

chr1_+_12325632 3.122 VPS13D
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr6_-_33268177 3.079 NM_001163771
NM_080679
NM_080680
NM_080681
COL11A2



collagen, type XI, alpha 2



chr13_+_110637173 3.060 NM_001113513
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr3_+_35696119 3.053 NM_001025068
NM_001025069
ARPP21

cAMP-regulated phosphoprotein, 21kDa

chr17_+_42641712 3.051 NM_002476
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr12_+_108038774 3.030 ACACB
acetyl-CoA carboxylase beta
chr1_+_158317967 3.025 NM_004983
KCNJ9
potassium inwardly-rectifying channel, subfamily J, member 9
chr7_-_41709191 3.024 NM_002192
INHBA
inhibin, beta A
chr1_-_154727014 2.996 MEF2D
myocyte enhancer factor 2D
chr3_+_129117007 2.989 KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr22_-_35545462 2.978 NM_002854
PVALB
parvalbumin
chr2_-_236837726 2.970 NM_212556
ASB18
ankyrin repeat and SOCS box containing 18
chr12_-_49689295 2.953 NM_001174130
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr10_+_88418147 2.923 NM_001171610
LDB3
LIM domain binding 3
chrX_+_152699616 2.905 NM_001170760
NM_001170761
NM_014370
SRPK3


SRSF protein kinase 3


chr6_+_131613196 2.901 NM_004842
NM_138633
AKAP7

A kinase (PRKA) anchor protein 7

chr8_+_67201684 2.891 NM_033058
NM_184085
NM_184086
NM_184087
TRIM55



tripartite motif containing 55



chr16_+_31132842 2.880 NM_001008274
TRIM72
tripartite motif containing 72
chr3_+_42702014 2.880 NM_152393
KBTBD5
kelch repeat and BTB (POZ) domain containing 5
chr13_-_50315832 2.859 NM_198989
DLEU7
deleted in lymphocytic leukemia, 7
chr17_-_10362583 2.838 NM_005963
MYH1
myosin, heavy chain 1, skeletal muscle, adult
chr15_+_66695932 2.812 NM_001190456
CORO2B
coronin, actin binding protein, 2B
chr8_-_27906287 2.805 NM_173833
SCARA5
scavenger receptor class A, member 5 (putative)
chr15_-_68781662 2.784 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr11_+_45072139 2.760 NM_020229
PRDM11
PR domain containing 11
chr2_-_162808123 2.748 NM_004460
FAP
fibroblast activation protein, alpha
chr2_+_102744921 2.728 NM_144632
TMEM182
transmembrane protein 182
chr16_+_82885821 2.688 NM_021197
WFDC1
WAP four-disulfide core domain 1
chr22_-_41366550 2.687 NM_001165877
ATP5L2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G2
chr4_-_1185144 2.671 LOC100130872
hypothetical LOC100130872
chr2_+_69055208 2.611 NM_019617
GKN1
gastrokine 1
chr5_-_142045770 2.606 NM_000800
FGF1
fibroblast growth factor 1 (acidic)
chr16_-_73798539 2.593 NM_001025200
CTRB1
CTRB2
chymotrypsinogen B1
chymotrypsinogen B2
chr16_-_31347151 2.591 NM_005205
COX6A2
cytochrome c oxidase subunit VIa polypeptide 2
chr12_-_49689255 2.590 SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr4_-_5881271 2.588 CRMP1
collapsin response mediator protein 1
chr21_-_35174742 2.574 RUNX1
runt-related transcription factor 1
chr1_+_26220852 2.570 NM_004455
EXTL1
exostoses (multiple)-like 1
chr7_+_30917939 2.547 NM_198098
AQP1
aquaporin 1 (Colton blood group)
chr9_+_115367122 2.546 NM_134427
RGS3
regulator of G-protein signaling 3
chr1_+_26220895 2.515 EXTL1
exostoses (multiple)-like 1
chr17_-_39094787 2.504 NM_001040002
MEOX1
mesenchyme homeobox 1
chr1_+_158352143 2.473 NM_000702
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr17_-_31441390 2.441 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chr3_-_48573556 2.428 PFKFB4
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
chr12_-_109842736 2.426 NM_000432
MYL2
myosin, light chain 2, regulatory, cardiac, slow
chr14_-_93493519 2.411 NM_016150
ASB2
ankyrin repeat and SOCS box containing 2
chr16_-_66535457 2.357 NM_000229
LCAT
lecithin-cholesterol acyltransferase
chr3_+_185300660 2.352 NM_182589
HTR3E
5-hydroxytryptamine (serotonin) receptor 3, family member E
chr17_+_42641426 2.345 NM_001002841
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr5_-_42847716 2.343 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr2_+_96818048 2.266 CNNM4
cyclin M4
chr12_-_47679459 2.263 DDN
dendrin
chr1_+_158426908 2.256 NM_001231
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr1_-_229071957 2.239 NM_001136494
C1orf198
chromosome 1 open reading frame 198
chr19_-_55912006 2.205 NM_016148
SHANK1
SH3 and multiple ankyrin repeat domains 1
chr2_-_165768798 2.200 NM_001081676
NM_001081677
NM_006922
SCN3A


sodium channel, voltage-gated, type III, alpha subunit


chr1_-_205012348 2.185 NM_000572
IL10
interleukin 10
chr10_+_70172257 2.157 CCAR1
cell division cycle and apoptosis regulator 1
chr5_-_66528330 2.155 NM_005582
CD180
CD180 molecule
chr12_+_118100977 2.155 NM_014365
HSPB8
heat shock 22kDa protein 8
chr2_+_44356100 2.152 NM_000341
SLC3A1
solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1
chr1_-_116112921 2.143 NM_001232
CASQ2
calsequestrin 2 (cardiac muscle)
chr2_-_217268492 2.132 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chr10_-_115413630 2.130 NM_006175
NM_198060
NRAP

nebulin-related anchoring protein

chr6_-_133126278 2.118 NM_078488
VNN2
vanin 2
chr10_+_21924265 2.102 MLLT10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
chr11_+_1817294 2.082 NM_001145829
TNNI2
troponin I type 2 (skeletal, fast)
chr19_+_4983899 2.081


chr10_+_91142301 2.068 NM_001548
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr1_+_144124547 2.063 NM_145277
NM_202004
NM_213652
NM_213653
HFE2



hemochromatosis type 2 (juvenile)



chr5_-_83052606 2.062 NM_001884
HAPLN1
hyaluronan and proteoglycan link protein 1
chr9_+_126094067 2.037 NM_001166170
NM_001166171
NEK6

NIMA (never in mitosis gene a)-related kinase 6

chr6_-_130224108 2.028 NM_001010876
C6orf191
chromosome 6 open reading frame 191
chr2_+_201182187 2.025 AOX1
aldehyde oxidase 1
chr8_+_17866373 2.024 PCM1
pericentriolar material 1
chr8_-_131483395 2.017 NM_018482
ASAP1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
chr17_-_45626364 1.996


chr14_+_77939845 1.987 NM_004796
NRXN3
neurexin 3
chr6_-_123999640 1.978 NM_006073
TRDN
triadin
chr6_+_136214495 1.974 NM_018945
PDE7B
phosphodiesterase 7B
chr16_+_14187965 1.963 MKL2
MKL/myocardin-like 2
chr3_-_11585264 1.939 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr18_-_49944986 1.918 MBD2
methyl-CpG binding domain protein 2
chr1_-_116112853 1.884 CASQ2
calsequestrin 2 (cardiac muscle)
chr1_+_181380837 1.872 LAMC1
laminin, gamma 1 (formerly LAMB2)
chr10_+_126620681 1.864 NM_017580
ZRANB1
zinc finger, RAN-binding domain containing 1
chr14_+_95792299 1.849 NM_000710
BDKRB1
bradykinin receptor B1
chr20_+_60558104 1.840 NM_178463
C20orf166
chromosome 20 open reading frame 166
chr9_-_129580732 1.831 NM_170600
SH2D3C
SH2 domain containing 3C
chr2_+_37282516 1.822 LOC100505876
hypothetical LOC100505876
chr2_-_190635566 1.815 NM_005259
MSTN
myostatin
chr1_+_213245507 1.797 NM_001017424
KCNK2
potassium channel, subfamily K, member 2
chr4_+_146820805 1.796 NM_001080531
C4orf51
chromosome 4 open reading frame 51
chr9_+_135387106 1.770 NM_001145320
ADAMTSL2
ADAMTS-like 2
chr11_-_30910074 1.769 NM_020869
DCDC5
doublecortin domain containing 5
chr7_-_76667045 1.759 NM_006682
FGL2
fibrinogen-like 2
chr1_-_228916486 1.744 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr14_+_71065794 1.743 NM_015556
SIPA1L1
signal-induced proliferation-associated 1 like 1
chr1_-_144426918 1.723 NM_007053
CD160
CD160 molecule
chr14_-_88090641 1.708 NM_007039
PTPN21
protein tyrosine phosphatase, non-receptor type 21
chr10_+_91082218 1.706 NM_001031683
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr3_-_46224791 1.705 NM_001295
CCR1
chemokine (C-C motif) receptor 1
chr6_-_169395972 1.703 NM_003247
THBS2
thrombospondin 2
chr17_-_26672757 1.698 NM_001003927
NM_014210
EVI2A

ecotropic viral integration site 2A

chr21_-_18697829 1.692 NM_002772
TMPRSS15
transmembrane protease, serine 15
chr9_+_126094388 1.690 NM_001166169
NEK6
NIMA (never in mitosis gene a)-related kinase 6
chr6_-_76259976 1.683 NM_015687
FILIP1
filamin A interacting protein 1
chr12_-_16652202 1.682 NM_001001395
LMO3
LIM domain only 3 (rhombotin-like 2)
chr7_+_100037817 1.681 NM_002593
PCOLCE
procollagen C-endopeptidase enhancer
chr2_+_149603226 1.664 NM_177964
LYPD6B
LY6/PLAUR domain containing 6B
chr4_-_169476391 1.663 NM_017631
DDX60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr10_+_111755715 1.660 NM_019903
ADD3
adducin 3 (gamma)
chr12_-_68379331 1.652 NM_032735
BEST3
bestrophin 3
chr4_+_111053488 1.648 NM_001178130
NM_001178131
NM_001963
EGF


epidermal growth factor


chr3_+_50291521 1.647 NM_153215
C3orf45
chromosome 3 open reading frame 45
chr7_+_18502342 1.646 NM_058176
NM_178425
HDAC9

histone deacetylase 9

chr10_+_71231693 1.640 COL13A1
collagen, type XIII, alpha 1
chr12_-_25041639 1.632 NM_001101339
C12orf77
chromosome 12 open reading frame 77
chr9_-_35640852 1.631 NM_014450
SIT1
signaling threshold regulating transmembrane adaptor 1
chr10_-_75071205 1.613 MYOZ1
myozenin 1
chr1_-_31618405 1.587 NM_004102
FABP3
fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
chr17_+_55098280 1.584 CLTC
clathrin, heavy chain (Hc)
chr1_-_116112684 1.583 CASQ2
calsequestrin 2 (cardiac muscle)
chr2_-_99412694 1.573 REV1
REV1 homolog (S. cerevisiae)
chr5_+_121493113 1.566 NM_207317
ZNF474
zinc finger protein 474
chrX_-_11194015 1.540 NM_013423
ARHGAP6
Rho GTPase activating protein 6

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.06 1.16e-06 GO:0007517 muscle organ development
2.63 3.41e-06 GO:0061061 muscle structure development
2.93 3.07e-05 GO:0003012 muscle system process
5.20 1.12e-03 GO:0030049 muscle filament sliding
5.20 1.12e-03 GO:0033275 actin-myosin filament sliding
5.07 1.60e-03 GO:0070252 actin-mediated cell contraction
2.62 5.87e-03 GO:0006936 muscle contraction
4.06 1.18e-02 GO:0030048 actin filament-based movement
2.76 1.28e-02 GO:0060537 muscle tissue development
2.70 2.77e-02 GO:0042692 muscle cell differentiation
2.76 3.02e-02 GO:0014706 striated muscle tissue development
2.96 4.16e-02 GO:0045765 regulation of angiogenesis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
4.34 4.11e-11 GO:0030016 myofibril
4.21 4.76e-11 GO:0043292 contractile fiber
4.19 6.15e-10 GO:0044449 contractile fiber part
4.23 1.19e-08 GO:0030017 sarcomere
1.68 1.13e-05 GO:0044421 extracellular region part
1.73 1.02e-04 GO:0005615 extracellular space
1.33 1.22e-02 GO:0005576 extracellular region
5.76 3.79e-02 GO:0032982 myosin filament

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.80 2.18e-03 GO:0008092 cytoskeletal protein binding
4.13 1.09e-02 GO:0008307 structural constituent of muscle
1.92 2.60e-02 GO:0003779 actin binding
9.25 3.89e-02 GO:0042805 actinin binding