Motif ID: MEF2{A,B,C,D}.p2

Z-value: 4.397


Transcription factors associated with MEF2{A,B,C,D}.p2:

Gene SymbolEntrez IDGene Name
MEF2A 4205 myocyte enhancer factor 2A
MEF2B 100271849 myocyte enhancer factor 2B
MEF2BNB-MEF2B 4207 MEF2BNB-MEF2B readthrough
MEF2C 4208 myocyte enhancer factor 2C
MEF2D 4209 myocyte enhancer factor 2D

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MEF2Cchr5_-_882356240.751.2e-03Click!
MEF2Dchr1_-_154737130-0.515.4e-02Click!
MEF2Achr15_+_979907050.371.8e-01Click!
MEF2Bchr19_-_19142053-0.195.0e-01Click!
LOC729991-MEF2Bchr19_-_19163916-0.107.2e-01Click!


Activity profile for motif MEF2{A,B,C,D}.p2.

activity profile for motif MEF2{A,B,C,D}.p2


Sorted Z-values histogram for motif MEF2{A,B,C,D}.p2

Sorted Z-values for motif MEF2{A,B,C,D}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MEF2{A,B,C,D}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_75085754 8.919 NM_001114133
SYNPO2L
synaptopodin 2-like
chr2_-_210876560 8.183 NM_079422
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr10_+_69539255 8.038 NM_032578
MYPN
myopalladin
chr17_-_31548167 7.924 NM_001001437
NM_021006
CCL3L3
CCL3
CCL3L1
chemokine (C-C motif) ligand 3-like 3
chemokine (C-C motif) ligand 3
chemokine (C-C motif) ligand 3-like 1
chr10_-_69095362 7.915 NM_001127384
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr12_+_79625538 7.848 NM_002469
MYF6
myogenic factor 6 (herculin)
chr12_-_55931172 7.409 NM_145064
STAC3
SH3 and cysteine rich domain 3
chr11_-_19180092 7.326 NM_001127656
NM_003476
CSRP3

cysteine and glycine-rich protein 3 (cardiac LIM protein)

chr2_+_88148413 7.134 NM_198274
SMYD1
SET and MYND domain containing 1
chr3_-_39209075 6.754 NM_194293
NM_001198621
XIRP1

xin actin-binding repeat containing 1

chr1_-_199657468 6.469 NM_003281
TNNI1
troponin I type 1 (skeletal, slow)
chr10_+_50177192 6.454 NM_001135196
NM_199459
C10orf71

chromosome 10 open reading frame 71

chr10_-_75080784 5.965 NM_024875
SYNPO2L
synaptopodin 2-like
chr4_+_169654742 5.849 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chr6_-_139654807 5.842 NM_153235
TXLNB
taxilin beta
chr4_-_23500706 5.833 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr1_+_154478574 5.661 NM_199173
BGLAP
bone gamma-carboxyglutamate (gla) protein
chr15_+_76345577 5.509 NM_001130183
DNAJA4
DnaJ (Hsp40) homolog, subfamily A, member 4
chr2_-_105421661 5.495 NM_201557
FHL2
four and a half LIM domains 2
chr2_-_179623030 5.411 NM_173648
CCDC141
coiled-coil domain containing 141

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 12 of 12 entries
enrichment   p-value GO term description
5.20 1.12e-03 GO:0030049 muscle filament sliding
5.20 1.12e-03 GO:0033275 actin-myosin filament sliding
5.07 1.60e-03 GO:0070252 actin-mediated cell contraction
4.06 1.18e-02 GO:0030048 actin filament-based movement
3.06 1.16e-06 GO:0007517 muscle organ development
2.96 4.16e-02 GO:0045765 regulation of angiogenesis
2.93 3.07e-05 GO:0003012 muscle system process
2.76 1.28e-02 GO:0060537 muscle tissue development
2.76 3.02e-02 GO:0014706 striated muscle tissue development
2.70 2.77e-02 GO:0042692 muscle cell differentiation
2.63 3.41e-06 GO:0061061 muscle structure development
2.62 5.87e-03 GO:0006936 muscle contraction

Gene overrepresentation in compartment category:

Showing 1 to 8 of 8 entries
enrichment   p-value GO term description
5.76 3.79e-02 GO:0032982 myosin filament
4.34 4.11e-11 GO:0030016 myofibril
4.23 1.19e-08 GO:0030017 sarcomere
4.21 4.76e-11 GO:0043292 contractile fiber
4.19 6.15e-10 GO:0044449 contractile fiber part
1.73 1.02e-04 GO:0005615 extracellular space
1.68 1.13e-05 GO:0044421 extracellular region part
1.33 1.22e-02 GO:0005576 extracellular region

Gene overrepresentation in function category:

Showing 1 to 4 of 4 entries
enrichment   p-value GO term description
9.25 3.89e-02 GO:0042805 actinin binding
4.13 1.09e-02 GO:0008307 structural constituent of muscle
1.92 2.60e-02 GO:0003779 actin binding
1.80 2.18e-03 GO:0008092 cytoskeletal protein binding